Which of the following cancers is NOT treated with methotrexate?

Which of the following cancers is NOT treated with methotrexate?

• A. Lung cancer
• B. Bladder cancer
• C. Prostate cancer
• D. Lymphoma

Answer: (C)

Methotrexate is a chemotherapy agent and immunomodulator that is utilized in the treatment of several cancers, particularly those that are particularly sensitive to its effects due to its mechanism of action. It works by inhibiting the metabolism of folate, which is necessary for DNA synthesis and cell division, thereby slowing down the proliferation of cancer cells. Lung cancer, bladder cancer, and lymphoma are all known to be treated with methotrexate due to their responsiveness to this drug, either as a sole agent or in combination with other therapies. For instance, lymphoma is often treated with methotrexate as part of a multi-agent chemotherapy regimen. In contrast, prostate cancer is not typically treated with methotrexate. Instead, prostate cancer treatment usually focuses on hormone therapy, surgical options, and other chemotherapeutic agents that are more effective for this type of cancer. The distinct biological behavior of prostate cancer, which is often driven by androgens, makes methotrexate less relevant in its treatment compared to the other cancers listed. This distinction clarifies why prostate cancer is the appropriate answer in this context.

Methotrexate is a chemotherapy agent and immunomodulator that is utilized in the treatment of several cancers, particularly those that are particularly sensitive to its effects due to its mechanism of action. It works by inhibiting the metabolism of folate, which is necessary for DNA synthesis and cell division, thereby slowing down the proliferation of cancer cells.

Lung cancer, bladder cancer, and lymphoma are all known to be treated with methotrexate due to their responsiveness to this drug, either as a sole agent or in combination with other therapies. For instance, lymphoma is often treated with methotrexate as part of a multi-agent chemotherapy regimen.

In contrast, prostate cancer is not typically treated with methotrexate. Instead, prostate cancer treatment usually focuses on hormone therapy, surgical options, and other chemotherapeutic agents that are more effective for this type of cancer. The distinct biological behavior of prostate cancer, which is often driven by androgens, makes methotrexate less relevant in its treatment compared to the other cancers listed. This distinction clarifies why prostate cancer is the appropriate answer in this context.